Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery
نویسندگان
چکیده
منابع مشابه
Metabolic Effects of Bariatric Surgery
Obesity and its associated comorbidities are an ongoing health care problem worldwide [1]. It is well known that obese patients are at increased risk for the development of diabetes, hypertension, hyperlipidemia, sleep apnea, osteoarthritis, and other degenerative diseases [2]. Bariatric surgery has demonstrated to achieve, on top of significant weight reduction, also long-term control of metab...
متن کاملMetabolic effects of bariatric surgery
Obesity is associated with an increased risk of type 2 diabetes, hypertension, dyslipidemia, cardiovascular disease, osteoarthritis, numerous cancers and increased mortality. It is estimated that at least 2.8 million adults die each year due to obesity-related cardiovascular disease. Increasing in parallel with the global obesity problem is metabolic syndrome, which has also reached epidemic le...
متن کاملFatty liver diseases, bile acids, and FXR
The prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide has increased at an alarming rate, which will likely result in enormous medical and economic burden. NAFLD presents as a spectrum of liver diseases ranging from simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even to hepatocellular carcinoma (HCC). A comprehensive understanding of the mechanism(...
متن کاملA surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery.
Bariatric surgery elevates serum bile acids. Conjugated bile acid administration, such as tauroursodeoxycholic acid (TUDCA), improves insulin sensitivity, whereas short-circuiting bile acid circulation through ileal interposition surgery in rats raises TUDCA levels. We hypothesized that bariatric surgery outcomes could be recapitulated by short circuiting the normal enterohepatic bile circulati...
متن کاملBile Acids and Metabolic Regulation
B ile acids have long been known to facilitate digestion and absorption of lipids in the small intestine as well as regulate cholesterol homeostasis (1,2). Over the last decade, however, it has become clear that bile acids are not simply digestive detergents and the primary route governing cholesterol catabolism. Bile acids are now recognized as hormones involved in the regulation of various me...
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ژورنال
عنوان ژورنال: Journal of Obesity
سال: 2016
ISSN: 2090-0708,2090-0716
DOI: 10.1155/2016/4390254